mark hurd new ipad 3 jodie fisher zooey deschanel yvette prieto hypertrophic cardiomyopathy kaye stevens
রবিবার, ২৫ নভেম্বর, ২০১২
Nokia imaging chief to quit
LONDON (Reuters) - Defence contractor BAE Systems may close one of its major shipyards in Britain as it looks to balance capacity with future workloads, a top executive has told a newspaper in an interview published on Sunday. Nigel Whitehead, who is group managing director, programmes and support, told the Sunday Telegraph that BAE, which operates a shipyard in Portsmouth and two in Glasgow, "anticipate(s) that there will be a reduction in footprint". "We anticipate ... that part of that might actually be the cessation of manufacturing at one of the sites," he was quoted as telling the paper. ...
Source: http://news.yahoo.com/nokia-imaging-chief-quit-100413555--finance.html
Fun Voting Locations atlanta falcons voting hours election results Doug Martin Barack Obama & Joe Biden
Congo government says no talks with M23 rebels before Goma pullout
GOMA, Democratic Republic of Congo (Reuters) - Congo's government will not negotiate with M23 rebels in the east of the Central African country until the rebels pull out of the city of Goma, a government spokesman said on Sunday.
Lambert Mende said President Joseph Kabila had met M23 representatives in Uganda for the first time on Saturday and had reiterated his readiness to consider their demands.
"Negotiations will start after the (M23) withdrawal from Goma. Even if we want to negotiate, this can't be before 48 hours," Mende said, referring to a deadline given to the rebels on Saturday. Regional leaders on Saturday called on the rebels to pull out of Goma.
(Reporting by Jonny Hogg; Writing by Richard Lough; Editing by Louise Ireland and James Macharia)
Source: http://news.yahoo.com/congo-government-says-no-talks-m23-rebels-goma-093113230.html
pekingese tcu football westminster bonnaroo 2012 lineup twisted metal sea lion si swimsuit
'Week of Service' invites Allstate employees to volunteer ? Business ...
Northbrook, Ill.-based Allstate this summer challenged its 70,000 em??ployees to partner with local nonprofit organizations in their communities?and it made a $500 grant to each of those nonprofits, awarding $80,000 overall.
The challenge came as part of the organization?s first Week of Service, during which employees collected enough food and money to provide almost 240,000 meals distributed through food banks supported by the Feeding America hunger-relief charity.
Before kicking off the service week, employee-led ?Helping Hands? committees coordinated volunteer opportunities around the country throughout the year.
The insurance giant donated more than $2 million to employee-chosen nonprofits last year.
Contact: Kyle Donash of Allstate, (847) 402-5600.
Like what you've read? ...Republish it and share great business tips!
Attention: Readers, Publishers, Editors, Bloggers, Media, Webmasters and more...
We believe great content should be read and passed around. After all, knowledge IS power. And good business can become great with the right information at their fingertips. If you'd like to share any of the insightful articles on BusinessManagementDaily.com, you may republish or syndicate it without charge.
The only thing we ask is that you keep the article exactly as it was written and formatted. You also need to include an attribution statement and link to the article.
" This information is proudly provided by Business Management Daily.com: http://www.businessmanagementdaily.com/33717/week-of-service-invites-allstate-employees-to-volunteer "
Source: http://www.businessmanagementdaily.com/33717/week-of-service-invites-allstate-employees-to-volunteer
oakland shooting mega millions winning numbers autism speaks ubaldo jimenez ncaa final country music awards autism awareness
Scientists describe elusive replication machinery of flu viruses
Friday, November 23, 2012
Scientists at The Scripps Research Institute (TSRI) have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to "see" one of influenza's essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus's vulnerabilities that are sure to be of interest to drug developers.
The report, which appears online in Science Express on November 22, 2012, focuses on influenza's ribonucleoprotein (RNP). RNPs contain the virus's genetic material plus the special enzyme that the virus needs to make copies of itself.
"Structural studies in this area had stalled because of the technical obstacles involved, and so this is a welcome advance," said Ian A. Wilson, the Hansen Professor of Structural Biology at TSRI and senior author of the report with TSRI Professors of Cell Biology Bridget Carragher and Clint Potter. "The data from this study give us a much clearer picture of the flu virus replication machinery."
Unveiling the Mystery of RNPs
At the core of any influenza virus lie eight RNPs, tiny molecular machines that are vital to the virus's ability to survive and spread in its hosts. Each RNP contains a segment?usually a single protein-coding gene?of the RNA-based viral genome. This viral RNA segment is coated with protective viral nucleoproteins and has a structure that resembles a twisted loop of chain. The free ends of this twisted loop are held by a flu-virus polymerase enzyme, which handles the two central tasks of viral reproduction: making new viral genomic RNA, and making the RNA gene-transcripts that will become new viral proteins.
Aside from its importance in ordinary infections, the flu polymerase contains some of the key "species barriers" that keep, for example, avian flu viruses from infecting mammals. Mutations at key points on the enzyme have enabled the virus to infect new species in the past. Thus researchers are eager to know the precise details of how the flu polymerase and the rest of the RNP interact.
Getting those details has been a real challenge. One reason is that flu RNPs are complex assemblies that are hard to produce efficiently in the lab. Flu polymerase genes are particularly resistant to being expressed in test cells, and their protein products exist in three separate pieces, or subunits, that have to somehow self-assemble. Until now, the only flu RNPs that have been reproduced in the laboratory are shortened versions whose structures aren't quite the same as those of native flu RNPs. Researchers also are limited in how much virus they can use for such studies.
The team nevertheless managed to develop a test-cell expression system that produced all of the protein and RNA components needed to make full-length flu RNPs. "We were able to get the cells to assemble these components properly so that we had working, self-replicating RNPs," said Robert N. Kirchdoerfer, a first author of the study. Kirchdoerfer was a PhD candidate in the Wilson laboratory during the study, and is now a postdoctoral research associate in the laboratory of TSRI Professor Erica Ollmann Saphire.
Kirchdoerfer eventually purified enough of these flu RNPs for electron microscope analysis at TSRI's Automated Molecular Imaging Group, which is run jointly by Carragher and Potter.
Never Seen Before
The imaging group's innovations enable researchers to analyze molecular samples more easily, in less time, and often with less starting material. "We were able, for example, to automatically collect data for several days in a row, which is unusual in electron microscopy work," said Arne Moeller, a postdoctoral research associate at the imaging group who was the other first author of the study.
Electron microscopes make high-resolution images of their tiny targets by hitting them with electrons rather than photons of light. The images revealed numerous well-defined RNP complexes. To Moeller and his colleagues' surprise, many of these appeared to have new, partial RNPs growing out of them. "They were branching?this was very exciting," he said.
"Essentially these were snapshots of flu RNPs being replicated, which had never been seen before," said Kirchdoerfer. These and other data, built up from images of tens of thousands of individual RNPs, allowed the team to put together the most complete model yet for flu-RNP structure and functions. The model includes details of how the viral polymerase binds to its RNA, how it accomplishes the tricky task of viral gene transcription, and how a separate copy of the viral polymerase assists in carrying out RNP replication. "We're now able to take a lot of what we knew before about flu virus RNP and map it onto specific parts of the RNP structure," said Kirchdoerfer.
The new flu RNP model highlights some viral weak points. One is a shape-change that a polymerase subunit?which grabs viral RNA and feeds it to the polymerase's active site on a second subunit?has to undergo during viral gene transcription. Another is key interaction between the polymerase and viral nucleoproteins. Flu RNPs are long and flexible, curving and bending in electron microscope images; and thus the structural model remains only modestly fine-grained. "You wouldn't be able to design drugs based on this model alone," said Kirchdoerfer, "but we now have a much better idea of how flu RNPs work, and that does suggest some possibilities for better flu drugs."
###
Scripps Research Institute: http://www.scripps.edu
Thanks to Scripps Research Institute for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
This press release has been viewed 57 time(s).
Source: http://www.labspaces.net/125443/Scientists_describe_elusive_replication_machinery_of_flu_viruses
KDKA Pumpkin Carving Ideas denver broncos Hurricane Sandy path opm daylight savings school closings
Pet gift guide: Locally made gifts your pet will love | OregonLive.com
Don?t forget your furry family members this holiday season. After all, they deserve to receive something back for all that free unconditional love they give you throughout the year.
Here are some suggestions featuring items made in Oregon or Southwest Washington:
Wild Chewz antler dog chews: These dog chews from Bend-based Double E Pet Products are made from naturally shed deer and elk antlers and can last for months. Antlers are chemical-free, work well for dogs with allergy issues and promote good dental health. Cost: $6.75-$26.50 at Pets on Broadway; also available at wildchewz.com or pet stores throughout Oregon.
Digs brand dog beds: After trying unsuccessfully to find edgy, colorful beds for her pet dogs, designer JJ De Sousa decide to make her own. She found a line of U.S.-made, durable outdoor fabric, hired a local seamstress and began selling them just last month. Cost: $95 for an 18-by-24 inch version; $125 for a 24-by-36 inch version. The machine-washable beds are available at Digs Inside & Out, 1829 N.E. Alberta St. in Portland; digs-pdx.com.
Woodin? You cat posts:?The natural cat posts handcrafted by Vancouver-based company Woodin? You pet products are built with tree bark, carpet and sisal rope; salvaged cabinet doors collected at construction sites serve as bases. ?Bark is a good way for cats to shed their nails because they gravitate naturally to it,? says co-owner Amy Krcek. Prices range from $25 to $200. Products are available at?woodinu.com,?Green Dog Pet Supply?and other local pet stores.
Green Pet Gifts gift baskets: In June, local pet sitter Rebecca Pillsbury launched Green Pet Gifts, an online store featuring gift baskets for cats, dogs and their humans packed with locally and regionally produced treats and products. Prices range from $24.95 to $79.95 (Black Friday discounts offered this weekend). A fun option for hikers is the Outdoor Dog Lover Basket, which features a Cycle Dog bowl, Dogranola, Oregon hiking guide and more, $79.95. Purchase online at greenpetgifts.com.
Organic catnip slugs: Your cat soon will be addicted to these refillable catnip toys made with organic catnip tucked into fabric samples ?rescued? from local interior design firms. The toys are made by Trillium Artisans, a Portland-based nonprofit community economic development program for local crafters. Prices range from $4.75-$8.25; find them at the Trillium Artisans downtown pop-up shop, 318 S.W. Taylor,at Pets on Broadway,?Green Dog Pet Supply and Western Pet Supply, or?online at?trilliumartisans.org.
?Photo by Lisa Gastelum of TQB Designs
Source: http://www.oregonlive.com/pets/index.ssf/2012/11/pet_gift_guide_locally_made_gi.html
Ed Hochuli Opie modern family george strait how i met your mother sons of anarchy PNC Bank
Home Improvement Information That Will Work For You ...
As long as you are willing to seek help and information, you can complete almost any of thousands of different home improvement projects. If home improvement projects are on your ?to do? list, then this article might prove helpful.
TIP! One important thing that can greatly improve your home is improving your windows. Get new windows! Use windows that are double glazed.
Installing a source of heat beneath a tile floor is simple and economical. Look into radiant heat equipment, especially if you want to replace your flooring anyway. The sales person will be able to guide you on which type of flooring should be used as well as the options available for radiant heating. This can also improve your home?s value significantly.
Make you home look great from the curb. Keep your yard nice by mowing the lawn and doing the edging. Have some nice shrubs around your property. Tidy up the yard. If your roof or exterior walls are stained, have them power-washed. Thoroughly clean your windows. This will all add to the first impression your home makes on anyone when they see it.
TIP! One of the best ways to improve the value and overall quality of your home is to upgrade the appliances. Normally upgrading appliances can net you double what was spent to purchase the appliances.
Old toothbrushes can be used to clean your house. They can be used for cleaning kitchen and bathroom faucets as well as car engines. The best part is that they cost nothing! There?s no need to purchase a brand new bush whenever you can use a free item that is just as effective. You can spend the money you save on something else.
Think about what you can afford before making any decisions about what to improve. Generally, you need to recoup the cost of the upgrades within 24 months in order for it to make financial sense. Avoid going over your budget.
TIP! Prior to beginning any project, consider how much of a return you will get from the money you spend on it. Look for projects that will add more value to your home so you eventually get a return on the time and money you invested.
As you improve your house, be certain to put your personal touch on things while making sure not to diverge too much from your neighbors. You don?t want to stick out as the only homeowner on the cul-de-sac with a tower on top of your home. Trying to sell a house that appears odd will make it difficult to sell.
Replacing the outlet covers in any room is an inexpensive and easy upgrade. Without you even realizing it, your outlets covers grow discolored over time, giving a dingy look in some cases. Installing new ones can help make everything look fresher.
TIP! Carpeting high traffic areas, like entryways and often-used hallways, is always financially a bad decision. Just a few days of a continuous rainstorm can stain your carpet with dirt and mud, making it look older than other carpeting that doesn?t receive much foot traffic.
Adding an extra bathroom can really increase the value of your home. This is especially useful if you have rooms on a floor that does not currently have a bathroom. It seems there are never enough bathrooms for the number of people who need to use them.
Even beginning home improvers can find benefit in fixing a leaky faucet. When you can respond to issues like this promptly, you reduce water waste and the potential for damages. You?ll see the difference on your water bill.
Add some bling to a boring corner by hanging big costume jewelry pieces on a coat rack. Only put costume jewelry here, not your prized heirlooms. A jewelry display will help to avoid tangles in your collection. Choose a few of your favorites that are worn often, and keep those accessible.
TIP! When you?re doing work on your roof, three-inch aluminum tape can help you deal with any minor cracks that you find in the roofing surface. To use the tape, simply remove the paper backing from the tape and apply over the crack.
Prior to going to the home improvement store, create a list of what you are going to need. Having this list of items will allow you to visit the store just one time and will help you be organized.
Now that you?ve seen these ideas and tips, you should be more prepared to start off your own home improvement projects. Use these tips to safely and creatively undertake future home improvement projects.
Source: http://insparenting.com/2282/home-improvement-information-that-will-work-for-you/
Jessie Andrews sofia vergara bloomberg bloomberg Daily Caller Staten Island Trick or Treat
এতে সদস্যতা:
পোস্টগুলি (Atom)